Opportunity Information: Apply for PA 19 090
The NIH Pathway to Independence Award (Parent K99/R00) is a two-phase NIH grant meant to help outstanding postdoctoral researchers move more quickly and securely into independent, tenure-track (or equivalent) faculty careers. Its central goal is to grow and sustain a strong pipeline of new NIH-supported investigators by funding the critical transition period when a researcher is shifting from mentored postdoctoral training to running an independent research program. In practice, the award supports a candidate first in a mentored phase (the K99 portion) and then, once they secure an eligible independent faculty position, in an independent phase (the R00 portion). This structure is intended to reduce the career gap that can occur between postdoctoral training and the first independent research grant, giving awardees a clearer runway to establish themselves, generate strong data, publish, and compete successfully for subsequent NIH funding.
This specific Funding Opportunity Announcement (PA-19-090) is tailored for applicants whose work involves what NIH classifies as a clinical trial but is still considered basic research. It is aimed at researchers proposing to lead independent basic experimental studies with humans, described in NIH guidance as "prospective basic science studies involving human participants." These are studies where human participants are prospectively assigned to conditions, meaning the investigator actively manipulates an independent variable (for example, assigning participants to different task conditions, exposures, stimuli, or experimentally controlled environments) and then measures biomedical or behavioral outcomes. The key point is that the purpose is to understand fundamental mechanisms or phenomena, not to test a product, treatment, or process with a direct practical application in mind. If the intent of the study is more applied, such as evaluating an intervention or product with a specific practical or translational goal, NIH directs applicants to use the companion announcement (PA-18-397) instead.
Eligibility in the posted summary spans a wide set of organizational applicant types across government, academic, nonprofit, and for-profit sectors. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations that are not federally recognized. It also includes public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in that nonprofit category listing); for-profit organizations (other than small businesses); and small businesses, along with other applicant categories NIH may allow under its general policies. The opportunity also explicitly highlights participation from institutions and organizations that serve specific communities, such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
At the same time, NIH places clear limits on foreign involvement at the applicant-organization level. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" as defined in the NIH Grants Policy Statement are allowed, meaning a U.S.-based applicant institution can include certain types of well-justified foreign collaboration or activities under NIH rules, even though a foreign institution cannot be the primary applicant.
Administratively, this is a discretionary grant opportunity offered by the National Institutes of Health (NIH), listed under multiple CFDA numbers (93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.307, 93.361, 93.853, 93.865, 93.866, 93.867), reflecting that different NIH Institutes and Centers may participate and support awards under their missions. The posting notes an original closing date of 2020-05-07 and a creation date of 2018-11-28. The award ceiling and expected number of awards are not specified in the provided source data, which typically means applicants must refer to the full FOA text and relevant NIH Institute/Center participation details for budget structure, duration limits, and Institute-specific policies.
Overall, this K99/R00 FOA is best understood as a career acceleration mechanism for top postdoctoral candidates who are ready to build independence and who plan to run rigorous basic experimental studies in humans that meet the NIH clinical trial definition but are fundamentally mechanistic rather than applied. It funds both the final stage of mentored development and the initial launch of an independent lab or research program, with the explicit intent of producing competitive, long-term NIH-funded investigators.Apply for PA 19 090
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.307, 93.361, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2018-11-28.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Education, Environment, Health, Income Security and Social Services
Next opportunity: HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional)
Previous opportunity: Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Peri-operative Pain (UM1 Clinical Trial Optional)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 19 090
Applicants also applied for:
Applicants who have applied for this opportunity (PA 19 090) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mentored Quantitative Research Development Award (Parent K25 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 089 Funding Number: PA 19 089 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required) Apply for PA 19 087 Funding Number: PA 19 087 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 086 Funding Number: PA 19 086 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: NeuroImaging Tools and Resources Collaboratory (R24 Clinical Trial Not Allowed) Apply for RFA EB 18 004 Funding Number: RFA EB 18 004 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $600,000 |
| HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) (Collaborative R34- Clinical Trial Not Allowed) Apply for RFA DA 19 029 Funding Number: RFA DA 19 029 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $225,000 |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) Apply for PAR 19 134 Funding Number: PAR 19 134 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $300,000 |
| HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) ( R34- Clinical Trial Not Allowed) Apply for RFA DA 19 036 Funding Number: RFA DA 19 036 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $225,000 |
| Limited Competition for a Connectome Coordination Facility (R24 Clinical Trial Not Allowed) Apply for RFA MH 20 210 Funding Number: RFA MH 20 210 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $900,000 |
| Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed) Apply for RFA OD 19 016 Funding Number: RFA OD 19 016 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Clinical Trials Development for Co-Occurring Conditions in Individuals with Down syndrome: Phased Awards for INCLUDE (R61/R33 Clinical Trials Required) Apply for RFA OD 19 018 Funding Number: RFA OD 19 018 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed) Apply for RFA OD 19 015 Funding Number: RFA OD 19 015 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $200,000 |
| PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required Apply for PA 19 273 Funding Number: PA 19 273 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed) Apply for PAR 19 276 Funding Number: PAR 19 276 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $50,000 |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 19 274 Funding Number: PAR 19 274 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Marmoset Coordination Center (U24 Clinical Trials Not Allowed) Apply for RFA MH 20 150 Funding Number: RFA MH 20 150 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed) Apply for RFA MH 20 145 Funding Number: RFA MH 20 145 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Blueprint for Neuroscience Research Education Program on Translational Devices (R25 Clinical Trial Not Allowed) Apply for RFA NS 20 003 Funding Number: RFA NS 20 003 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $250,000 |
| NIH Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP-ENDURE) (R25 Clinical Trial Not Allowed) Apply for RFA NS 20 015 Funding Number: RFA NS 20 015 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed) Apply for RFA OD 20 004 Funding Number: RFA OD 20 004 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 20 142 Funding Number: PA 20 142 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 19 090", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.