High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) | PAR 25 277

Opportunity Information: Apply for PAR 25 277

The NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is offering the High Impact, Interdisciplinary Science in NIDDK Research Areas award (RC2; clinical trial optional) under funding opportunity PAR-25-277. This program is designed to back ambitious, high-impact projects that bring together expertise across different disciplines and could ultimately open up entirely new directions or subfields within areas NIDDK supports. The emphasis is on work that does more than add incremental knowledge: the expectation is that successful projects will generate broadly useful outputs, such as research resources, major datasets, enabling technologies, or discovery-driven and hypothesis-generating findings that the wider research community can build on.

A central theme of the opportunity is acceleration. NIDDK is looking for novel approaches that directly tackle important knowledge gaps or take advantage of timely scientific opportunities. Proposed work may focus on developing or applying new technologies, generating high-value data, creating innovative methods, or establishing platforms and resources that make future studies faster or more powerful. While the notice does not limit projects to a single disease area, the work must clearly align with NIDDKs mission, which broadly covers diabetes, endocrinology and metabolic diseases, digestive diseases, nutrition-related research, and kidney, urologic, and hematologic diseases, with the ultimate goal of improving understanding, treatment, and prevention.

The award uses the NIH grant mechanism and falls under the broader activity categories of food and nutrition and health, with CFDA number 93.847. Clinical trials are optional, meaning an application may include a clinical trial if it is scientifically justified, but a clinical trial is not required. The opportunity is listed as discretionary funding, and the original closing date shown is 2027-10-15.

Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations other than small businesses; small businesses; and other organizations. The notice also highlights categories of organizations that are explicitly welcomed as applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and Indian/Native American tribal governments that are not federally recognized.

Foreign organizations are not eligible to apply as the applicant organization. However, non-U.S. components of U.S. organizations are eligible to be part of an application, and foreign components are allowed consistent with NIH Grants Policy Statement definitions and requirements. In practical terms, that means the applicant institution must be domestic, but the project may include certain international elements or collaborations when appropriately justified and permitted under NIH policy.

Overall, this opportunity is best suited for teams that can credibly integrate multiple fields to create something enabling and field-shaping, such as a new experimental or computational platform, a foundational dataset or resource, or a cross-cutting method that unlocks new research directions in NIDDK-relevant diseases and biology.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2024-12-11.
• Applicants must submit their applications by 2027-10-15.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 25 277

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