Opportunity Information: Apply for PAR 18 608
Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) funding opportunity aimed at pushing forward new and highly innovative methods and technologies in natural products research. Natural products chemistry broadly covers the discovery, characterization, and development of chemical compounds produced by living organisms (such as plants, microbes, and marine life), and this FOA is focused on improving the underlying tools and approaches that make that work faster, more accurate, more scalable, or otherwise more impactful. The announcement is designed around methods development rather than clinical testing, and it explicitly states that clinical trials are not allowed under this mechanism.
The opportunity uses the Small Business Technology Transfer (STTR) mechanism, specifically the R41/R42 grant types, which are commonly structured in two stages. The R41 phase is typically used for early feasibility and proof-of-concept work, while the R42 phase is generally intended for further development, refinement, and steps toward commercialization or broader adoption. The core idea is to support small business concerns (SBCs) that can translate innovative ideas into practical technologies, while formally partnering with a research institution as required under STTR rules. In other words, it is meant for projects where a small business is leading the effort but also leveraging academic or nonprofit research strengths to build something new for the natural products field.
Eligibility is centered on small businesses. Foreign institutions (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply as applicant organizations. However, the FOA notes that foreign components may be allowed under NIH policy definitions, meaning certain project elements could potentially involve international collaborators or activities if they meet NIH requirements and are justified, but the primary applicant must be an eligible U.S. small business and the overall structure must comply with NIH rules.
From a categorization standpoint, this is a discretionary grant in the health funding activity category, listed under CFDA number 93.213, and administered by NIH. The funding opportunity number is PAR-18-608, and the original closing date listed is February 26, 2018, indicating this specific announcement was tied to that submission window. The published source data does not provide an award ceiling or an expected number of awards in the excerpt provided, so applicants would normally need to consult the full FOA text and NIH budget guidelines for the relevant STTR phases to understand typical funding levels, allowable costs, and project period limits.
In practical terms, the FOA is about enabling advances in how natural products are found, analyzed, purified, structurally characterized, dereplicated, synthesized or modified, or otherwise handled in research and development settings. The emphasis on "highly innovative methods and technologies" signals that NIH is looking for approaches that meaningfully move the field forward rather than incremental improvements, and that are appropriate for development within a small business-driven translational framework. The "Clinical Trial Not Allowed" restriction keeps the scope focused on technology and method development rather than testing interventions in human participants.Apply for PAR 18 608
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
- This funding opportunity was created on 2018-01-30.
- Applicants must submit their applications by 2018-02-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Next opportunity: Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R41/R42 Clinical Trial Not Allowed)
Previous opportunity: Mentored Research Scientist Development Award (Parent K01 -Independent Clinical Trial Not Allowed)
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Applicants who have applied for this opportunity (PAR 18 608) also looked into and applied for these:
| Funding Opportunity |
|---|
| Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Not Allowed) Apply for PA 18 607 Funding Number: PA 18 607 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44 Clinical Trial Not Allowed) Apply for PA 18 610 Funding Number: PA 18 610 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Mentored Career Transition Award for Intramural Fellows (K22 Clinical Trials Required) Apply for PA 18 613 Funding Number: PA 18 613 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Exploratory Clinical Trials for Small Business (R44) - Clinical Trial Required Apply for PAR 18 618 Funding Number: PAR 18 618 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Exploratory Clinical Trials for Small Business (R42) - Clinical Trial Required Apply for PAR 18 617 Funding Number: PAR 18 617 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Mentored Career Transition Award for Intramural Fellows (K22 Clinical Trials Not Allowed) Apply for PA 18 614 Funding Number: PA 18 614 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R41/R42 Clinical Trial Not Allowed) Apply for PA 18 609 Funding Number: PA 18 609 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Disease Mechanisms of Prenatal and Pediatric Hydrocephalus (R01 Clinical Trial Not Allowed) Apply for PA 18 622 Funding Number: PA 18 622 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tools to Enhance the Study of Prenatal and Pediatric Hydrocephalus (R21 Clinical Trial Not Allowed) Apply for PA 18 623 Funding Number: PA 18 623 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Research to Support the Reduction and Elimination of Mental Health Disparities (Admin Supp Clinical Trial Optional) Apply for PA 18 621 Funding Number: PA 18 621 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Understanding Processes of Recovery in the Treatment of Alcohol Use Disorder (R21 - Clinical Trial Optional) Apply for PA 18 620 Funding Number: PA 18 620 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Understanding Processes of Recovery in the Treatment of Alcohol Use Disorder (R01 - Clinical Trial Optional) Apply for PA 18 619 Funding Number: PA 18 619 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Dementia Care and Caregiver Support Interventions (R01 - Clinical Trial Required) Apply for RFA AG 18 030 Funding Number: RFA AG 18 030 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| NIBIB Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) Apply for PA 18 631 Funding Number: PA 18 631 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIMH Biobehavioral Research Awards for Innovative New Scientists (NIMH BRAINS) (R01 Clinical Trial Optional) Apply for RFA MH 19 130 Funding Number: RFA MH 19 130 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required) Apply for PAR 18 633 Funding Number: PAR 18 633 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Academic Research Enhancement Award for Mechanistic and Minimal Risk Human Subjects' Research (R15 Clinical Trial Optional) Apply for PA 18 635 Funding Number: PA 18 635 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) Apply for PAR 18 632 Funding Number: PAR 18 632 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Investigator Initiated Extended Clinical Trial (R01 Clinical Trial Required) Apply for PAR 18 630 Funding Number: PAR 18 630 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional) Apply for PAR 18 628 Funding Number: PAR 18 628 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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