Opportunity Information: Apply for PA 18 033
The National Institutes of Health (NIH) funding opportunity titled "Characterization of the Adolescent Reproductive Transition (R01 Clinical Trial Optional)" (Funding Opportunity Number: PA 18 033; CFDA: 93.865) is a discretionary grant program that supports research aimed at improving scientific understanding of puberty and the broader trajectory of sexual development during adolescence. The central focus is on characterizing normative (typical) sexual maturation in both males and females, with an emphasis on how adolescents progress through puberty and ultimately establish reproductive competence. In practice, this means NIH is looking to fund strong, well-justified projects that can clarify what healthy reproductive development looks like, how it unfolds over time, and which biological processes and measurable markers best capture that transition.
A key theme of the announcement is that important knowledge gaps still exist in basic and translational understanding of puberty, despite its obvious relevance to lifelong health. The FOA specifically encourages investigators to use new technologies and modern research approaches to address these gaps. This could include more precise hormonal profiling, advanced imaging, genetic or epigenetic methods, novel biosensors, improved analytic techniques for longitudinal data, or other cutting-edge tools that can capture the timing, sequencing, and variability of pubertal changes. The expectation is that better measurement and better models of normal development will strengthen the field overall, improving the ability to distinguish typical variation from patterns that may signal risk for later reproductive, metabolic, bone, cardiovascular, or mental health concerns.
The grant mechanism is an R01, which generally supports substantial, multi-year research projects that are hypothesis-driven or otherwise rigorously designed, and that can produce meaningful, publishable advances in a field. The listing states "Clinical Trial Optional," meaning applicants may propose studies that include a clinical trial if it is scientifically appropriate, but they are not required to do so. In other words, projects can range from observational human studies (for example, tracking pubertal milestones and biomarkers over time) to interventional studies that meet the NIH definition of a clinical trial, as long as the work aligns with the FOA's goal of advancing understanding of adolescent reproductive development.
Eligibility is broad and includes many types of organizations capable of conducting health-related research. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations. This broad eligibility signals an intent to encourage diverse institutions and communities to contribute to, and benefit from, research on adolescent development.
From the administrative details provided, the opportunity was created on 2017-11-03 and listed an original closing date of 2019-09-07. The award ceiling, expected award count, and similar funding specifics are not provided in the supplied text, so applicants would typically need to consult the full FOA and related NIH budget guidance for limits, project period norms, and review considerations. Overall, the opportunity is designed to catalyze high-quality, modern research that maps the adolescent reproductive transition more clearly, ultimately strengthening scientific baselines for puberty and improving the field's ability to understand reproductive health across the lifespan.Apply for PA 18 033
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Characterization of the Adolescent Reproductive Transition (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2017-11-03.
- Applicants must submit their applications by 2019-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Characterization of the Adolescent Reproductive Transition (R01 Clinical Trial Optional)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA 18 033.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.865.
What is the main purpose of this grant program?
This discretionary NIH grant program supports research aimed at improving scientific understanding of puberty and the broader trajectory of sexual development during adolescence, with a central focus on characterizing normative (typical) sexual maturation in both males and females.
What does NIH mean by "characterizing the adolescent reproductive transition"?
In this context, it means clarifying what healthy reproductive development looks like, how adolescents progress through puberty over time, and which biological processes and measurable markers best capture the transition through puberty and the establishment of reproductive competence.
Does the FOA focus on typical development or disorders of puberty?
Based on the provided description, the central focus is on normative (typical) sexual maturation and establishing strong scientific baselines for what normal development looks like and how it unfolds over time.
Why is this research area considered important by NIH?
The announcement emphasizes that important knowledge gaps remain in basic and translational understanding of puberty, despite its relevance to lifelong health. Improving measurement and models of normal development can strengthen the field and help distinguish typical variation from patterns that may signal later health risks.
What kinds of long-term health areas could be informed by better understanding of puberty?
The provided description notes that improved baselines may help identify patterns that signal risk for later reproductive, metabolic, bone, cardiovascular, or mental health concerns.
What research approach does NIH encourage for this opportunity?
The FOA encourages investigators to use new technologies and modern research approaches to address gaps in understanding puberty, including improved measurement and analytic methods that can capture timing, sequencing, and variability of pubertal changes.
What are examples of "new technologies" or "modern research approaches" mentioned?
Examples specifically mentioned include more precise hormonal profiling, advanced imaging, genetic or epigenetic methods, novel biosensors, and improved analytic techniques for longitudinal data, as well as other cutting-edge tools relevant to measuring pubertal development.
Is this opportunity limited to studies in one sex?
No. The central focus explicitly includes normative sexual maturation in both males and females.
What is the grant mechanism for this opportunity?
The mechanism is an NIH R01 grant.
What does an R01 generally support?
As described in the provided text, an R01 generally supports substantial, multi-year research projects that are hypothesis-driven or otherwise rigorously designed and intended to produce meaningful, publishable advances in the field.
What does "Clinical Trial Optional" mean for this FOA?
"Clinical Trial Optional" means applicants may propose studies that include a clinical trial if scientifically appropriate, but they are not required to do so.
Are observational studies allowed under this funding opportunity?
Yes. The description indicates projects can include observational human studies, such as tracking pubertal milestones and biomarkers over time, as long as the work aligns with the FOA's goals.
Are interventional studies allowed under this funding opportunity?
Yes. Interventional studies that meet the NIH definition of a clinical trial may be proposed if they align with the FOA's goal of advancing understanding of adolescent reproductive development.
Who is eligible to apply for this NIH grant?
Eligibility is broad. Eligible applicants include various government entities, school districts, public and private institutions of higher education, tribal governments and organizations, housing authorities, nonprofits (with or without 501(c)(3) status, if not institutions of higher education), for-profit organizations (other than small businesses), small businesses, and other entities.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list includes federally recognized Native American tribal governments and tribal organizations that are not federally recognized.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA explicitly highlights U.S. territories or possessions as additional eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly highlights non-U.S. (foreign) organizations as eligible.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly highlights faith-based or community-based organizations as additional eligible applicants.
Are minority-serving institutions specifically highlighted as eligible?
Yes. The FOA explicitly highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs, among other eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA explicitly highlights eligible federal agencies as additional eligible applicants.
Are small businesses eligible to apply?
Yes. Small businesses are included in the eligibility list.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations (other than small businesses) are included in the eligibility list, and small businesses are also listed as eligible.
Does the provided information include an award ceiling or expected number of awards?
No. The supplied text states that the award ceiling, expected award count, and similar funding specifics are not provided.
Where would an applicant typically look for budget limits or project period expectations?
Based on the provided text, applicants would typically consult the full FOA and related NIH budget guidance for limits, project period norms, and review considerations.
When was this opportunity created?
The opportunity was created on 2017-11-03.
What closing date is listed in the provided information?
An original closing date of 2019-09-07 is listed.
What is the overall goal of funding projects under this FOA?
The overall goal is to catalyze high-quality, modern research that maps the adolescent reproductive transition more clearly, strengthens scientific baselines for puberty, and improves the field's ability to understand reproductive health across the lifespan.
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| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03 Clinical Trial Optional) Apply for PAR 18 095 Funding Number: PAR 18 095 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
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| NCMRR Early Career Research Award (R03 Clinical Trial Optional) Apply for PAR 18 211 Funding Number: PAR 18 211 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $100,000 |
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