Opportunity Information: Apply for PAR 22 158
The Alcohol Treatment and Recovery Research (R01 Clinical Trial Required) funding opportunity (PAR 22-158) is a discretionary NIH grant administered by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It supports investigator-initiated research projects that include a clinical trial component and that aim to improve the treatment of, and long-term recovery from, alcohol use disorder (AUD). The overall intent is to advance practical, evidence-based approaches that can reduce harmful drinking, improve patient outcomes, and strengthen recovery trajectories across diverse populations and real-world care settings.
The scope is intentionally broad and covers the full pipeline from treatment development through implementation-relevant clinical research. NIAAA is interested in studies focused on medications development for AUD, including testing pharmacotherapies or medication strategies that can improve abstinence, reduce heavy drinking, or address relapse risk. The announcement also highlights precision medicine approaches, which generally means tailoring treatment based on individual differences such as clinical profiles, co-occurring conditions, genetics/biomarkers, drinking patterns, or other predictors of treatment response. In addition, the FOA emphasizes behavioral therapies and the mechanisms of behavioral change (MOBC), encouraging clinical trials that not only test whether an intervention works, but also examine how and why it works by measuring mediators, active ingredients, and change processes that drive outcomes.
Beyond acute treatment, the opportunity explicitly includes recovery research, recognizing that AUD is often a chronic, relapsing condition and that sustained recovery can involve multiple pathways and supports over time. Projects may address recovery maintenance, relapse prevention, recovery supports and services, and factors that influence long-term functioning and quality of life. The FOA also welcomes translational research that moves promising findings toward clinical application, as well as innovative methods and technologies for treatment and recovery. This can include novel intervention delivery models, digital or telehealth tools, technology-enabled monitoring and support, new assessment approaches, or other methodological innovations that improve engagement, personalization, reach, or effectiveness of care.
The mechanism is an R01, meaning it is designed for substantial, hypothesis-driven projects with a defined clinical trial. The funding instrument is a grant in the Health activity category (CFDA 93.273). While the provided listing does not specify an award ceiling or the expected number of awards, the R01 format typically supports multi-year projects of significant scope, and applicants are generally expected to propose a rigorous design, a strong analytic plan, and clear milestones appropriate for a clinical trial.
Eligibility is broad and includes many types of domestic U.S. applicants, such as state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); and small businesses. The FOA also calls out additional eligible applicant categories that NIH specifically encourages, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Non-domestic (non-U.S.) entities (foreign organizations) are also listed as eligible, which can be important for international collaborations or studies conducted outside the United States when well-justified by the science.
Key administrative details from the source include the agency (National Institutes of Health, via NIAAA), the opportunity number (PAR 22-158), and the original closing date shown as 2023-05-07, with a creation date of 2022-04-07. In practical terms, the announcement is aimed at supporting clinical trial research that can lead to more effective, more personalized, and more scalable AUD treatments, while also improving understanding of the mechanisms and recovery processes that sustain long-term change.Apply for PAR 22 158
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Treatment and Recovery Research (R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on 2022-04-07.
- Applicants must submit their applications by 2023-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Alcohol Treatment and Recovery Research (R01 Clinical Trial Required).
What is the opportunity number?
The opportunity number is PAR 22-158.
Which federal agency and NIH institute administer this grant?
This is a discretionary NIH grant administered by the National Institutes of Health (NIH) through the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main purpose of this grant?
The purpose is to support investigator-initiated research projects that include a clinical trial component and aim to improve the treatment of and long-term recovery from alcohol use disorder (AUD). The overall intent is to advance practical, evidence-based approaches that reduce harmful drinking, improve patient outcomes, and strengthen recovery trajectories across diverse populations and real-world care settings.
What type of NIH award mechanism is used?
The mechanism is an R01, intended for substantial, hypothesis-driven projects with a defined clinical trial.
Is a clinical trial required under this funding opportunity?
Yes. The opportunity is explicitly labeled "Clinical Trial Required", and it supports projects that include a clinical trial component.
What kinds of research are within the scope of this FOA?
The scope is intentionally broad and covers the full pipeline from treatment development through implementation-relevant clinical research. It includes treatment-focused research, recovery research, translational research to move findings toward clinical application, and innovative technologies and methods that improve engagement, personalization, reach, or effectiveness of care.
Does NIAAA support medications development for AUD under this opportunity?
Yes. NIAAA expresses interest in studies focused on medications development for AUD, including testing pharmacotherapies or medication strategies aimed at improving abstinence, reducing heavy drinking, or addressing relapse risk.
Are precision medicine approaches encouraged?
Yes. The announcement highlights precision medicine approaches, broadly described as tailoring treatment based on individual differences such as clinical profiles, co-occurring conditions, genetics/biomarkers, drinking patterns, or other predictors of treatment response.
Are behavioral therapies included in the scope?
Yes. The FOA emphasizes behavioral therapies and encourages clinical trials that test interventions and also examine the mechanisms of behavioral change.
What does "mechanisms of behavioral change (MOBC)" mean in this FOA?
In this FOA, MOBC refers to research that examines how and why a behavioral intervention works by measuring potential mediators, active ingredients, and change processes that drive clinical outcomes, rather than only testing whether the intervention works.
Does the FOA include research beyond acute treatment (long-term recovery)?
Yes. The opportunity explicitly includes recovery research, recognizing AUD as a potentially chronic, relapsing condition and emphasizing sustained recovery pathways and supports over time.
What recovery topics are appropriate for proposed projects?
Projects may address topics such as recovery maintenance, relapse prevention, recovery supports and services, and factors influencing long-term functioning and quality of life.
Are real-world care settings and diverse populations part of the intended focus?
Yes. The intent includes strengthening recovery trajectories across diverse populations and real-world care settings, with an emphasis on practical and scalable, evidence-based approaches.
Does the FOA support translational research?
Yes. The FOA welcomes translational research that moves promising findings toward clinical application.
Are innovative technologies and new delivery models allowed?
Yes. The FOA welcomes innovative methods and technologies for treatment and recovery, including novel intervention delivery models, digital or telehealth tools, technology-enabled monitoring and support, and new assessment approaches.
What is the funding instrument and activity category?
The funding instrument is a grant in the Health activity category.
What is the CFDA number listed for this opportunity?
The listing includes CFDA 93.273.
Is there an award ceiling or expected number of awards provided in the listing?
No. The provided listing does not specify an award ceiling or the expected number of awards.
What level of project scope does the R01 mechanism imply?
The R01 format is described as supporting multi-year projects of significant scope, with expectations for a rigorous design, a strong analytic plan, and clear milestones appropriate for a clinical trial.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic U.S. applicants, including various government entities, educational institutions, nonprofits, for-profits (other than small businesses), and small businesses, as well as tribal governments and tribal organizations. The FOA also lists non-U.S. entities (foreign organizations) as eligible.
Which U.S. government entities are eligible?
Eligible government applicants include state, county, city/township, and special district governments.
Are public housing authorities eligible to apply?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
Are institutions of higher education eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are independent school districts eligible?
Yes. Independent school districts are listed as eligible.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofits with and without 501(c)(3) status (outside of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are federally recognized tribal governments eligible?
Yes. Federally recognized Native American tribal governments are listed as eligible.
Are tribal organizations that are not federally recognized eligible?
Yes. Tribal organizations that are not federally recognized are listed as eligible.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are called out among eligible applicant categories NIH encourages.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility list includes non-domestic (non-U.S.) entities (foreign organizations), which may support international collaborations or studies conducted outside the U.S. when scientifically justified.
Which additional applicant categories does NIH specifically encourage for this FOA?
The FOA calls out additional eligible categories NIH encourages, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
What is the original closing date shown in the source information?
The original closing date shown is 2023-05-07.
What is the creation date shown for the opportunity?
The creation date shown is 2022-04-07.
What outcomes is this FOA trying to improve?
The FOA is aimed at improving outcomes such as reduced harmful drinking, improved patient outcomes, and stronger long-term recovery trajectories, including real-world effectiveness across diverse populations and care settings.
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